Which Chicago skyscraper was called “The Empire State Building on Nutrisystem?”
Click to see the answer
The Mather Tower (75 East Wacker Drive).
In the Mystery Science Theater 3000 episode 419, the space-bound trio make fun of the 1959 movie The Rebel Set, in which a group of beatniks from California pull off a bank robbery during a layover at Dearborn Station in Chicago during a cross-country train trip from Los Angeles to New York. Crow T. Robot utters the snark in question.
Note the transmitting antenna on top of the Mather Tower. If anyone knows what it was used for, let the rest of us know in the comment space below.